LncRNA OGFRP1 acts as an oncogene in NSCLC via miR-4640-5p/eIF5A axis

Abstract Background Long noncoding RNAs (lncRNAs) OGFRP1 is up-regulated in endometrial cancer and cervical carcinoma, suppression inhibits the malignant behavior of cells. Here, we evaluated expression pattern, biological function potential mechanism non-small cell lung (NSCLC). Methods The target genes 25 pairs clinically collected NSCLC normal tissue samples was detected by qRT-PCR or western blot. We screened siRNA (siOGFRP1) to down-regulate A549 H1299 cells were examined CCK8, wound healing transwell assays. molecular further explored. Results tissues higher than that tissue. siOGFRP1 inhibited proliferation, migration invasion In addition, EMT-related apoptosis-related proteins changed transfection. can directly interact with miR-4640-5p, increased level miR-4640-5p. Moreover, miR-4640-5p could bind 3’ UTR region eIF5A mRNA. highly expressed tissues, predicted a poor prognosis. negatively correlated, while positively correlated. Knockdown eIF5A, transfection inhibitor eIF5A. Conclusions Taken together, demonstrated down-regulation progression through miR-4640-5p/eIF5A axis.